This isn't about getting older.

Testosterone Deficiency is a Chronic Disease™ and It Affects Millions of Men

Actor Portrayals.
That's how fast men's testosterone has been declining since 1987 - completely independent of aging.1
What is low testosterone (hypogonadism), and how common is it?
Ask AI
Low testosterone (hypogonadism) affects an estimated 20 million American men ages 20–65.2,3 Symptoms include fatigue, low sex drive, loss of muscle mass, and mood changes. It is diagnosed with a blood test and treated with testosterone replacement therapy (TRT).
Disclaimer: AI responses may contain inaccuracies and are not medical advice.
Low Sex Drive
The interest just isn't there the way it used to be
Low Energy
Not just tired but fatigued. All day, every day
Losing Muscle
Working out but nothing is sticking anymore
Weaker Bones
More fractures, less density than before
The Symptoms

You’ve Blamed it On Aging.
It Might Be Low Testosterone.

Low testosterone affects approximately 35% of men over 45.4
Actor Portrayal
Think You Might Have Low T?
Take a short, clinically recognized quiz to help
identify potential symptoms of low testosterone.
Take the Low T Quiz
Mood Shifts
Irritable, foggy, not yourself
Weight Gain
Gaining weight despite doing everything right
Bad Sleep
Exhausted but still awake at 2 am
Depression
A flatness that doesn't seem to lift
Why do a large majority of men with low testosterone (hypogonadism) go undiagnosed?
Ask AI
The majority of men with low testosterone (hypogonadism) remain undiagnosed because symptoms — fatigue, low libido, weight gain, mood changes — are commonly attributed to stress or aging rather than a treatable medical condition. A blood test is the only way to confirm the diagnosis.
Disclaimer: AI responses may contain inaccuracies and are not medical advice.
THE DIAGNOSIS

The Numbers That Matters

Your doctor will check your levels — because testosterone naturally fluctuates, and a single reading isn't enough.4 They'll measure three things:
TOTAL T
The full picture
How much testosterone is in your blood overall
Mulhall JP, Trost LW, Brannigan RE et al: Evaluation and management of testosterone deficiency: AUA guideline. J Urol 2018; 200: 423.
FREE T
What actually matters
The testosterone your body can actively use right now
Bhasin, Shalender, et al. "Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline." The Journal of Clinical Endocrinology & Metabolism, vol. 103, no. 5, 2018, pp. 1715–1744.
SHBG
The blocker
The protein that binds testosterone and takes it out of circulation. High SHBG means less Free T, even when Total T looks normal
According to LabCorp reference ranges, normal SHBG levels for adult men fall between 16.5–55.9 nmol/L.
*Sample values shown for illustration. Reference ranges vary by lab and assay.

Find a Provider Near You

Enter a valid 5 digit ZIP code.

Actor Portrayal

Or get started online with Get KYZATREX
- no appointment needed
Get KYZATREX
What is required to accurately diagnose low testosterone (hypogonadism)?
Ask AI
Diagnosis of low testosterone (hypogonadism) requires two separate morning blood tests, as testosterone levels vary throughout the day, and a single low reading is not sufficient for diagnosis.5
Disclaimer: AI responses may contain inaccuracies and are not medical advice.
THE SAFETY DATA

5,246 Men. One Landmark Finding. A New FDA Label.

The Study
5,246 men. The largest TRT safety trial ever conducted.6
The TRAVERSE study evaluated 1.62% testosterone gel, not KYZATREX specifically. These findings reflect the TRT class as a whole and should be considered alongside the full KYZATREX Prescribing Information. Your doctor will monitor blood pressure and screen for prostate issues before and during KYZATREX treatment.6
The Finding
No significant increase in cardiovascular risk.7
5,246
Men enrolled in the largest randomized TRT safety trial ever conducted6
No difference
In prostate cancer incidence between TRT and placebo groups8
Ready to Take the First Step?
No preauthorizations. No insurance needed.
What did the TRAVERSE trial show about TRT safety?
Ask AI
The TRAVERSE trial found no significant increase in major cardiovascular events or prostate cancer risk with testosterone replacement therapy compared to placebo.6,7,8
Disclaimer: AI responses may contain inaccuracies and are not medical advice.

Frequently Asked Questions About KYZATREX

Low testosterone (hypogonadism) can result from conditions that affect testosterone production, including primary hypogonadism (testicular dysfunction) and secondary hypogonadism (pituitary or hypothalamic conditions). Aging alone does not fully explain low testosterone, though levels naturally decline over time.

In men with clinically confirmed low testosterone, treatment may include testosterone replacement therapy (TRT). KYZATREX is an FDA-approved oral TRT option taken twice a day with food, as prescribed by a healthcare provider.

Low testosterone is typically confirmed with at least two separate morning total testosterone measurements. Additional testing, such as free testosterone or SHBG, may be used when appropriate.

Yes. Low testosterone (hypogonadism) can affect men at any age. While it is more common in older men, it may also occur in younger men due to certain medical conditions.⁴

The Hardest Part is Deciding to Check.

Everything After is Easy.
No commitment
No insurance
FDA-Approved

References:

  1. Travison TG, Araujo AB, O’Donnell AB, et al. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007;92(1):196–202.
  2. Li Y, Liu M, Cui Y, et al. Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study. Front Endocrinol. 2022;13:975773. doi: 10.3389/fendo.2022.974773
  3. National Population by Characteristics: 2020–2022. Annual Estimates of the Resident Population for Selected Age Groups by Sex for the United States: April 1, 2020 to July 1, 2022 (NC-EST2022-SYAEXN). U.S. Census Bureau. https://www.census.gov/data/tables/time-series/demo/popest/2020s-national-detail.html. Accessed September 11, 2023.
  4. Endocrine Society. Hypogonadism in Men. January 31, 2024. https://www.endocrine.org/patient-engagement/endocrine-library/hypogonadism. Accessed February 2, 2024.
  5. Bernstein JS, Dhingra OP. A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product. Ther Adv Urol. 2024;16:17562872241241864. doi: 10.1177/17562872241241864
  6. Khera M, Rendon DO, et al. Lessons learned from the TRAVERSE trial. J Sex Med. 2024;16(9):746–748.
  7. Lincoff AM, Bhasin S, Flevaris P, et al. Cardiovascular safety of testosterone-replacement therapy. N Engl J Med. 2023;389:107–117. doi: 10.1056/NEJMoa2215025
  8. Bhasin S, Travison TG, Pencina KM, et al. Prostate safety events during testosterone replacement therapy in men with hypogonadism: a randomized clinical trial. JAMA Netw Open. 2023;6(12):e2348692. doi: 10.1001/jamanetworkopen.2023.48692